Time to shift the thinking around hypos

Dr Aveni Haynes

The Kids researchers have shed new light on long-held clinical evidence about blood glucose control in kids with type 1 diabetes (T1D) – giving parents more clarity to help keep their kids safe and well, now and into the future.

The word ‘hypo’ might be small, but these low glucose level episodes are the number one fear of families living with a child with T1D, as they can potentially lead to convulsions, coma or even death in severe cases.
Compounding this fear has been the belief, based on historical evidence, that good blood glucose control increases the risk of severe hypoglycaemia — a confusing message for parents striving to keep their child well without putting them in harm’s way.

Thankfully, new research from the Children’s Diabetes Centre at The Kids Research Institute Australia has found these two outcomes are no longer linked, with clinicians now in the driver’s seat to re-frame the way they deliver hypo education to families to help alleviate some of this fear.

The paradigm-shifting findings came out of a longitudinal study led by Dr Aveni Haynes, head of epidemiology research at the Centre. The study, which featured on the cover of the prestigious Diabetes Care journal in September 2019, looked at trends in glycaemic control (a medical term referring to the typical levels of blood glucose in a person with T1D) and hypoglycaemia rates in paediatric cohorts from Western Australia, Germany and Austria.

The study found that the relationship between a patient’s average level of blood glucose and severe hypoglycaemia events had changed over the past two decades in countries where modern diabetes therapies and technology were being used to treat children with T1D. 

“For people living with type 1 diabetes, the ongoing challenge is for them to optimise their blood glucose control to minimise their long-term risk of diabetes-related complications, without increasing their risk of severe hypoglycaemia — it’s a 24/7 juggle for families.

“If you are teaching that glycaemic control increases the risk of severe hypoglycaemia, there is a natural hesitation from families about how far they want to go to improve blood glucose levels. Now that we know this is less of a risk, the challenge for clinicians is to re-frame how we talk about severe hypos so we are not driving that fear at the expense of better glycaemic control.”

Dr Haynes said the study provided strong support for a personalised approach for blood glucose control, as well as a revision of the historical dogma that linked improved glycaemic control with severe hypo risk.

“This will require a shift in the clinical approach and education aimed at reducing the fear of hypos for patients and their carers so that optimal glycaemic control can be achieved in more individuals with T1D, improving their short and longer-term diabetes-related morbidity and quality of life,” she said.

“Although the fear of severe hypoglycaemia will always be present, this study will hopefully help to alleviate some of this fear and give more clarity around hypo risk and glycaemic control so parents can feel more confident in keeping their child with diabetes safe and healthy.”

What’s Next

• Raising awareness about this evidence among patients and health professionals.
• Changing the way diabetes teams provide diabetes education to families, resulting in improved glycaemic control, better health outcomes and less complications.