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Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges

We describe recent "omic"-level findings, and examine how these findings have been systematically integrated to generate further insight

Factors associated with adherence to antimicrobial stewardship after-hours

Restricted antimicrobials acquired after-hours are not routinely antimicrobial stewardship adherent at the time of acquisition or the next standard working day

Early lung disease in infants and preschool children with cystic fibrosis: What have we learned and what should we do about it?

This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and research

Perth scientist receives prestigious honour

An internationally recognised researcher at The Kids Research Institute Australia has been made a Fellow of the Australian Academy of Science

Social disadvantage the focus for WA child health researchers

Researchers from The Kids will play a significant role in investigating - and breaking - the generational cycle of social disadvantage.

Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers

Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.

Altered dietary behaviour during pregnancy impacts systemic metabolic phenotypes

Evidence suggests consumption of a Mediterranean diet (MD) can positively impact both maternal and offspring health, potentially mediated by a beneficial effect on inflammatory pathways. We aimed to apply metabolic profiling of serum and urine samples to assess differences between women who were stratified into high and low alignment to a MD throughout pregnancy and investigate the relationship of the diet to inflammatory markers.  

Incidence and survival for childhood cancer by endorsed non-stage prognostic indicators in Australia

Nick Gottardo MBChB FRACP PhD Head of Paediatric and Adolescent Oncology and Haematology, Perth Children’s Hospital; Co-head, Brain Tumour Research

Clinical Trials in the Brain Tumour Population: Challenges and Strategies for the Future

This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years.

Research Assistant - END RHD CRE

The Opportunity The Kids Research Institute Australia is leading the work to end rheumatic heart disease (RHD) as a public health priority for