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Research

Climate change, activism, and supporting the mental health of children and young people: Perspectives from Western Australia

The climate crisis has detrimental impacts on the mental health and wellbeing of children and young people. Psychological effects include feelings of fear, overwhelm, worry, distress, hopelessness and anger; PTSD; depression; anxiety; phobias; panic disorder; sleep disturbances; attachment disorders; learning difficulties; substance abuse; shock and trauma symptoms; adjustment problems; behavioural problems; and, suicidal thinking.

Research

Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

Genetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from diverse prokaryal genomes to screen MMIs promoting the nuclear relocalization of Forkhead Box O3 (FOXO3a), a tumor suppressor more frequently inactivated by post-translational modification than mutation.

Infectious Disease Ecology and Modelling

The Infectious Disease Ecology and Modelling team led by Professor Nick Golding, combines mathematical and statistical modelling, ecology, and public health to address malaria and other infectious and vector-borne diseases. The team uses modelling and maps to measure the risk posed by some of the world’s most important and neglected diseases – including malaria, Japanese Encephalitis Virus and Covid-19 – and provide rapid modelling analyses to policy makers.

Neonatal Health

Preterm babies have a heightened risk of infection as their immune system is not mature. The Neonatal Health Team is exploring new ways to diagnose, prevent and treat infections in WA's smallest patients .

Research

Mind The Distance

Yael Penelope Keely Bep Amy Helen Perry Strauss Bebbington Uink Finlay-Jones Milroy BPsych (Hons) MPsych (Clin) PhD BA, MPH, PhD MClinPsych/PhD

Strep A & ARF Therapeutics

The Strep A & ARF Therapeutics research team are working to accelerate research and clinical trials to improve penicillin formulation and treatment methods, to end RHD.

Research

Undiagnosed Diseases Program (UDP) and Bringing the benefits of precision medicine to children in Western Australia

We have started a project utilising whole genome sequencing of undiagnosed children living in WA to provide a definitive diagnosis. A major challenge here is that the role and functions of the inter-genic regions of our genome (the remaining 98%) are relatively poorly understood.

Research

An unbiased exploration of the human regulatory landscape

We are made up of hundreds of different cell types carrying out a diverse range of functions essential for organism survival. All the information required to specify the morphology, function and response to stimuli of these cells is encoded in identical copies of the genome. The process of gene regu

RHD in Australia

Rheumatic heart disease (RHD) is a preventable,devastating condition that disproportionately affects Aboriginal and Torres Strait Islander Australians.

Research

Ngangk Ngabala Ngoonda (Sun Safety)

The Ngangk Ngabala Ngoonda (Sun Safety) project aims to address an urgent health issue and knowledge gap by generating a greater understanding of the barriers to sun protective behaviours and skin cancer prevention among Aboriginal CYP and their families in WA.