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ORIGINS Adventures at the Telethon Family Festival

We loved seeing so many families at the ORIGINS marquee at the Telethon Family Festival at Optus Stadium

New video: Diabetes in Schools

Anthony and Zavier's mum Lucy talks about her contrasting school experiences in dealing with her sons' type 1 diabetes - with and without the support of the Diabetes in Schools program.

Papers & Publications

Publications, papers and findings coming out of ORIGINS and its sub-projects

Rural Cancer Siblings

We want to hear from siblings living outside of Australian cities!

Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A Streptococcus population

Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new genotyping scheme for the pilin adhesin and backbone genes is developed and, when combined with emm typing, provides an account of the global GAS strain population.

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1beta signaling plays an important role in GAS disease progression.

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages

Podcast

Embracing the Mind is hosted by Embrace senior researchers Dr Alix Woolard and Dr Karen Lombardi.

Sibling Stories

Researchers from The Kids Research Institute Australia are seeking young people (aged 14-25) who have a trans or gender diverse sibling aged 25 or under to take part in a new study.

Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP

Our results suggest that intracellular infection with the pathogenic GAS M1T1 clone induces a strong pro-inflammatory response in primary tonsil epithelial cells