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Research
Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by HydroxychloroquineWe propose that hydroxychloroquine could be repurposed to reduce the risk of rheumatic heart disease after acute rheumatic fever
Research
Environmental and social determinants of acute rheumatic fever: a longitudinal cohort studyPrevention strategies in ARF endemic settings may be enhanced by targeting new members entering a community and children in environments of close contact
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Prospective cohort study of childhood behaviour problems and adolescent sexual risk-taking: Gender mattersThis study sought to determine relationships, by gender, between childhood behaviour problems and adolescent risky sexual behaviours and substance use.
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2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart diseaseRheumatic heart disease (RHD) is an important and preventable cause of morbidity and mortality among children and young adults in low-income and middle-income countries, as well as among certain at-risk populations living in high-income countries. The 2012 World Heart Federation echocardiographic criteria provided a standardized approach for the identification of RHD and facilitated an improvement in early case detection.
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Penicillin G concentrations required for prophylaxis against Group A Streptococcus infection evaluated using a hollow fibre model and mathematical modellingAcute rheumatic fever (ARF), an autoimmune reaction to Group A Streptococcus (Streptococcus pyogenes; Strep A) infection, can cause rheumatic heart disease (RHD). New formulations of long-acting penicillins are being developed for secondary prophylaxis of ARF and RHD.
Research
Evaluation of a Community-Led Program for Primordial and Primary Prevention of Rheumatic Fever in Remote Northern AustraliaEnvironmental factors including household crowding and inadequate washing facilities underpin recurrent streptococcal infections in childhood that cause acute rheumatic fever (ARF) and subsequent rheumatic heart disease (RHD).
Latest news & events at the Wesfarmers Centre of Vaccines & Infectious Diseases.
Research
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic feverA sample target product profile for reformulated benzathine penicillin G is presented
Research
Focused cardiac ultrasound screening for rheumatic heart disease by briefly trained health workers: A study of diagnostic accuracyEchocardiographic screening for rheumatic heart disease (RHD) can identify individuals with subclinical disease who could benefit from antibiotic prophylaxis.
News & Events
Skin infections send eight out of every 100 Aboriginal babies to hospitalIn a WA first, researchers from The Kids Research Institute Australia have shown that Aboriginal babies are 22.5 times more likely to be treated for skin infections than non-Aboriginal babies.