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Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in children ≥2 years with cystic fibrosis: 96-week interim results from a phase 3 open-label extension study

Elexacaftor/tezacaftor/ivacaftor(ELX/TEZ/IVA) was safe and efficacious in children with CF 2-5y with at least one F508del allele in 24-week phase 3 T…

Comparative evaluation of performance and precision of multiplex immunoassays measuring human IgG to Streptococcus pyogenes vaccine antigens

Streptococcus pyogenes (Group A Streptococcus, Strep A) is a Gram-positive bacterium and one of the most significant global bacterial pathogens, with…

Tracking Health Related Quality of Life From Diagnosis to Follow-Up Among Australian Children With Acute Lymphoblastic Leukaemia

Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment-rela…

Growing Up Rural: Rurality as a Predictor of Child Mental Health in an Australian Cohort

There is a paucity of longitudinal research comparing early-life mental health in rural and metropolitan communities. Living in rural areas is associ…

Effectiveness and Cost-Effectiveness of Models of Healthcare for People With Intellectual Disability in Australia: A Scoping Review

People with intellectual disability experience significant gaps in healthcare delivery resulting in poor health outcomes. Appropriately designed heal…

Establishing a Clinically Relevant Radiation Therapy Method for Preclinical Medulloblastoma Research

Craniospinal irradiation (CSI) is a cornerstone of pediatric brain cancer therapy, yet detailed, reproducible protocols for accurate CSI delivery in…

Body Mass Index Trajectories Among Patients with Drug-Susceptible and Drug-Resistant Tuberculosis in Northwest Ethiopia

A retrospective cohort study was conducted using clinical data from patients attending TB clinics at four public hospitals in Northwest Ethiopia. We…

Malaria in Papua New Guinean infants: a prespecified analysis of a randomised postpartum antimalarial treatment trial

There are scant and variable data concerning the incidence of malaria in infants in endemic areas. This study evaluated the impact of maternal antima…

A Single-Armed Pilot Study to Evaluate a Psychosocial Intervention for Young People Who Have Experienced a Burn Injury: The Wellbeing Study

Children with serious burns often suffer psychosocial consequences. This study evaluated the pilot of a 6-session psychoeducational intervention newl…

Stochastic models indicate rapid smallpox spread and mass mortality of Indigenous Australians after colonial exposure

The impact of smallpox (variola) on Aboriginal communities in Australia beginning in 1789 was catastrophic and continues to cause intergenerational t…