Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained
This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
We report an 8 year old girl who was diagnosed with THES by the Undiagnosed Disease Program-WA with compound heterozygous pathogenic variants in SKIV…
There is a critical need for the field to develop and implement strategies to understand the mechanisms underlying all rare diseases and translate th…
We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system
Our result highlighted that miRNA-target gene network contributes to human disease genetics in a cell type-specific manner
Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors
We are made up of hundreds of different cell types carrying out a diverse range of functions essential for organism survival. All the information req…
Current technologies to understand which genes are turned on or off only work on large amounts of biological samples. As a consequence all measuremen…
We have started a project utilising whole genome sequencing of undiagnosed children living in WA to provide a definitive diagnosis. A major challenge…