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Research

Improving Outcome Reporting in Paediatric Airway Management in Clinical Trials (IMPACT): A Study Protocol for Core Outcomes and Clinical Endpoints

Although clinical trials are fundamental to advancing evidence-based practice, significant heterogeneity in outcome reporting poses a considerable challenge to the validity of systematic reviews. This inconsistency impedes the ability to compare, synthesise and interpret research findings effectively. In the field of paediatric airway management, this issue is particularly relevant because of the low incidence of critical events and the related high morbidity and mortality. The issue of inadequate and variable outcome reporting in clinical trials has been widely acknowledged, necessitating initiatives to enhance the quality of future research.

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The public health control of scabies: priorities for research and action

Scabies causes considerable morbidity and leads to severe bacterial infection and immune-mediated disease

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Validation of monoclonal anti-PKC isozyme antibodies for flow cytometry analyses in human T cell subsets and expression in cord blood T cells

We have undertaken to validating the specificity of commercially available antibodies marketed for flow cytometry to measure PKCα, βI, βII, δ, ε, η, θ, ζ, ι/λ and μ

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Call for a national sore throat guideline

Australia needs a single national pharyngitis guideline to assist in providing rational, consistent and timely antibiotic treatment to patients at high risk of ARF

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Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

We review the Group A Streptococcus Human infection studies and present the study protocol for a dose-ranging inpatient study in healthy adults

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Gender-affirming hormones and surgery in transgender children and adolescents

This Review explores the available published evidence on gender-affirming cross-sex hormone and surgical interventions in transgender children

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Functional genomics in cancer immunotherapy: Computational approaches for biomarker and drug discovery

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response

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Reduced heart rate variability in adults with autism spectrum disorder

Our data suggest an overall dysregulation in resting autonomic activity in adults with autism spectrum disorder

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Still keen and committed: piloting an instrument for identifying positive veteran teachers

Initial findings suggest the potential of the instrument in helping identifying positive veteran teachers within systems, as well as the voracity of the research approach