Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer-related death in chi…
Cancer cells are addicted to polyamines, polycations essential for cellular function. While dual targeting of cellular polyamine biosynthesis and pol…
Kairalla JA, Hibbitts E, …….. Kotecha RS, Guest E. Age-based pegaspargase dosing
Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare.
In pediatric cancer precision medicine clinical trials settings, parents proactively seeking treatment and answers to causation may request return of…
The RNA-binding protein IGF2BP3 is an oncofetal protein overexpressed in B-acute lymphoblastic leukemia and is critical for leukemogenesis in experim…
Preemptive pharmacogenomic (PGx) testing in pediatric oncology patients could reduce toxicity and improve efficacy of medications yet remains underut…
Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear whic…
Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by…
In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloi…