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An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion

Functional studies of how early-life interventions shape the airway microbiome remain scarce. Here, we performed metagenomic sequencing of 704 longitudinal nasal swabs from infants with and without cystic fibrosis (CF) to construct and characterize a non-redundant gene atlas of the infant nasal microbiome. We aimed to determine how the nasal microbiome is perturbed by early therapies, as CF is commonly treated with inhaled hypertonic saline to improve mucociliary clearance.

Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes

These findings suggest the utility of specific FOT outcomes is dependent on the respiratory disease being assessed

Parents welcome follow-up using mobile devices: A survey of acceptability at an Australian tertiary paediatric centre

We surveyed 642 parents and carers at Perth Children's Hospital, targeting demographics, device ownership and attitudes towards electronic follow-up

Statistical Analysis Plan for "An international study of isoelectric electroencephalography events in infants and young children during anesthesia for surgery"

This Statistical Analysis Plan details the statistical procedures to be applied for the analysis of data for the multicenter electroencephalography study

Respiratory function in healthy Emirati children using forced oscillations

Forced oscillation technique measurements were feasible in Emirati school-children. New forced oscillation technique reference equation in Emirati children were derived.

Increased prevalence of expiratory flow limitation during exercise in children with bronchopulmonary dysplasia

Expiratory flow limitation is more prevalent in children born preterm with bronchopulmonary dysplasia and is associated with airway obstruction

Deep or awake removal of laryngeal mask airway in children at risk of respiratory adverse events undergoing tonsillectomy - a randomised controlled trial

We found no evidence for a difference in the timing of the laryngeal mask airways removal on the incidence of respiratory adverse events

The impact of respiratory viruses on lung health after preterm birth

The aim of this review is to highlight the risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants

Increasing diversity within the Global Lung Function Initiative

The Global Lung Function Initiative has worked to develop all‐age, multi‐ethnic reference equations for the major clinical lung function tests

Early lung surveillance of cystic fibrosis: what have we learnt?

Newborn screening (NBS) for cystic fibrosis (CF) provides an opportunity to commence management and therapeutic interventions significantly earlier