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Research

Respiratory infection and wheezing illness are leading causes of hospitalisation in childhood, placing a significant burden on families and healthcare systems. However, reliably distinguishing children at risk of developing persistent disease from those likely to outgrow their symptoms remains a clinical challenge. Earlier identification would allow clinicians to focus care and resources on those most likely to benefit from long-term management, while reducing anxiety and uncertainty about the future for families.

Research

In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures.

Research

The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children

Research

Human Respiratory Syncytial Virus and Human Rhinovirus are the most frequent cause of respiratory tract infections in infants and children and are major triggers of acute viral bronchiolitis, wheezing and asthma exacerbations.

Research

In healthy individuals, deep inspirations (DIs) taken prior to a bronchial challenge reduce the bronchoconstrictor response, which is termed...

Research

With the emergence of allergic and autoimmune diseases in populations that have started to transit to a western lifestyle, there has been an increasing...

Research

Early immunological influences on asthma development: opportunities for early intervention

Research

IgE antibodies in house dust mite (HDM) allergy follow a predictable pattern. Half are directed against two dominant allergens and the remainder largely against

News & Events

Asthma researchers at Perth's The Kids for Child Health Research are developing a world first system for predicting the severity of asthma in children

News & Events

The Kids Research Institute Australia researchers are investigating whether a simple urine test could predict whether young children with wheezing symptoms will go on to develop asthma.