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Research
Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small CohortVaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the success of future vaccine development efforts. We applied cutting edge multi-omics approaches to extensively characterize temporal molecular responses following vaccination with hepatitis B virus (HBV) vaccine. Data were integrated across cellular, epigenomic, transcriptomic, proteomic, and fecal microbiome profiles, and correlated to final HBV antibody titres.
Research
Predicting immune protection against outcomes of infectious disease from population-level effectiveness data with application to COVID-19Quantifying the extent to which previous infections and vaccinations confer protection against future infection or disease outcomes is critical to managing the transmission and consequences of infectious diseases. We present a general statistical model for predicting the strength of protection conferred by different immunising exposures (numbers, types, and strains of both vaccines and infections), against multiple outcomes of interest, whilst accounting for immune waning.
Research
Atypical nested 22q11.2 duplications are associated with neurodevelopmental phenotypes including autism spectrum disorder with incomplete penetranceOur findings contribute to the genotype–phenotype data for atypical nested 22q11.2 duplications, with implications for genetic counseling
News & Events
Rapid diagnosis for childhood brain cancer in WAThe Kids Research Institute Australia's Brain Tumour Research team will develop and implement cutting-edge technologies to revolutionise the speed of brain cancer diagnosis for WA children, thanks to more than $200,000 from Telethon.
News & Events
Why it’s safe for kids to be at schoolAs Australia battles with COVID-19 outbreaks across all mainland states, there is a sense of familiar dread as major cities plunge into lockdown.
News & Events
Improving aftercare for young people at risk of suicideA collaborative research team has secured federal funding to examine ways to improve the experience that children, adolescents and young people have when they present to hospital emergency departments for an acute mental health crisis with the aim of reducing the rate of youth suicide.
News & Events
Could Perth lakes hold the secret to fighting antibiotic-resistant superbugs?Perth researchers have discovered a predatory virus living in the city’s lakes and rivers that can fight antibiotic-resistant superbugs in children.
News & Events
Bold bid to end rheumatic heart diseaseSome of the nation’s leading medical researchers will converge on Darwin this week to step out a plan to wipe out rheumatic heart disease.
News & Events
Tribute to Dr Clyde HertzmanResearchers at Perth's The Kids for Child Health Research are mourning the sudden passing of Canadian child development expert Dr Clyde Hertzman
Research
A randomised-controlled trial of a parent-mediated intervention for managing uncertainty in young children diagnosed on the autism spectrumGail Andrew Videos Alvares Whitehouse Watch and listen to Andrew PhD PhD Senior Research Fellow Deputy Director (Research); Angela Wright Bennett