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Research
Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is usedSurgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of around 45% for non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at the time of surgery for staging purposes, and this cannot be a null event for patient survival and future response to immune checkpoint blockade treatment. This project investigates cancer surgery, lymphadenectomy, onset of metastatic disease, and response to immunotherapy in a novel model that closely reflects the clinical setting. In a murine metastatic lung cancer model, primary subcutaneous tumours were resected with associated dLNs remaining intact, completely resected or partially resected.
Research
Antenatal creatine supplementation reduces persistent fetal lung inflammation and oxidative stress in an ovine model of chorioamnionitisChorioamnionitis is a common antecedent of preterm birth and induces inflammation and oxidative stress in the fetal lungs. Reducing inflammation and oxidative stress in the fetal lungs may improve respiratory outcomes in preterm infants. Creatine is an organic acid with known anti-inflammatory and antioxidant properties.
Research
Improving immunity to Haemophilus influenzae in children with chronic suppurative lung diseaseEndobronchial infections related to non-typeable Haemophilus influenzae (NTHi) are common in children and adults with suppurative airway disease...
Research
Levels of innate immune factors in preterm and term mothers' breast milk during the 1st month postpartumPreterm breast milk contains significantly higher concentrations of some immune proteins than term breast milk
Research
Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental AllergyThe pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of...
Research
Nasopharyngeal carriage of Streptococcus pneumoniae: prevalence and risk factors in HIV-positive children in TanzaniaPneumococcal colonization of the nasopharynx is especially common in young children and is a pre-requisite for pneumococcal disease...
News & Events
The Kids STEM Festival returns for two days of free family fun in BroomeThe Kids Research Institute Australia will return to the Kimberley in May for the Broome STEM Festival, promising two fun-filled days of hands-on science activities for local families to experience.
News & Events
Celebrating CONNECTAt The Kids Research Institute Australia, we’ve always known what a fantastic community we have around us.
News & Events
Cheers as Beau’s curls cut to fund cancer fightA brave young man stepped up to the plate on Friday to do his part in the battle against cancer.
News & Events
Government funding for innovative sun safety online tool for teensThe Kids researcher Dr Shelley Gorman has received a Healthway grant to develop an online tool to promote safe sun behaviours to teenagers.