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Research
Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is usedSurgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of around 45% for non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at the time of surgery for staging purposes, and this cannot be a null event for patient survival and future response to immune checkpoint blockade treatment. This project investigates cancer surgery, lymphadenectomy, onset of metastatic disease, and response to immunotherapy in a novel model that closely reflects the clinical setting. In a murine metastatic lung cancer model, primary subcutaneous tumours were resected with associated dLNs remaining intact, completely resected or partially resected.
Research
Nasopharyngeal carriage of Streptococcus pneumoniae: prevalence and risk factors in HIV-positive children in TanzaniaPneumococcal colonization of the nasopharynx is especially common in young children and is a pre-requisite for pneumococcal disease...
Our team of world-class researchers and exceptional clinicians work in collaboration to provide children access to the very best evidence-based therapies and programs.
Research
END RHDGlenn Jonathan Katharine Rosemary Pearson Carapetis AM Noonan Wyber BA (Education) PhD Candidate AM MBBS FRACP FAFPHM PhD FAHMS MBBS (Hons) MSc
Research
Modeling the potential health impact of prospective Strep A vaccinesThe World Health Organization published the preferred product characteristics for a Group A Streptococcus (Strep A) vaccine in 2018. Based on these parameters for the age of vaccination, vaccine efficacy, duration of protection from vaccine-derived immunity, and vaccination coverage, we developed a static cohort model to estimate the projected health impact of Strep A vaccination at the global, regional, and national levels and by country-income category.
Research
Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescentsUsing prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin...
News & Events
Survivors of drug-resistant TB face long-term health problems: studyNew research highlights the long-term physical health problems faced by people who survive drug-resistant tuberculosis (TB) .
News & Events
My child is being bullied - how do I support them?As a parent, it can be very stressful to learn that your child is being bullied. Our instinct is to protect our children at all costs - but how exactly should we do this?
News & Events
Video intervention offers promising language boost for kids showing early signs of autismThe first rigorous trial of a pre-emptive behavioural intervention for babies showing early signs of autism has found the therapy can improve early language development.
News & Events
New study reveals Rett syndrome can strike malesA new study has found that the genetic flaw responsible for Rett syndrome can strike males, even where there isn't a family history of the rare brain disorder.