Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through…
Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigen…
IgE-mediated food allergies have been linked to suboptimal naïve CD4 T (nCD4T) cell activation in infancy, underlined by epigenetic and transcriptomi…
Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence t…
Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring. We investigated the association betw…
Prenatal alcohol exposure is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA…
Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic microorganisms. Dysbio…
T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cyc…
In Western countries, Asian children have higher food allergy risk than Caucasian children. The early-life environmental exposures for this discrepan…