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Research
"Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New ZealandFour-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG.
Research
Does otitis media in early childhood affect later behavioural development? Results from the Western Australian Pregnancy Cohort (Raine) StudyThe relationship between early life episodes of otitis media and later behavioural development with adjustment for confounders.
Research
The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in salivaWe have developed an LC-MS/MS assay that accurately measures saliva 25(OH)D3 levels, which correlated with serum levels
News & Events
Return to school measures build confidenceWA parents and carers can have confidence in sending their children back to school on January 31 with the measures outlined in today’s Safe Return to School Plan.
Research
Safety, tolerability, and effect of a single aural dose of Dornase alfa at the time of ventilation tube surgery for otitis media: A Phase 1b double randomized control trialOne third of children require repeat ventilation tube insertion (VTI) for otitis media. Disease recurrence is associated with persistent middle ear bacterial biofilms. With demonstration that Dornase alfa (a DNase) disrupts middle ear effusion biofilms ex vivo, we identified potential for this as an anti-biofilm therapy to prevent repeat VTI. First, safety and tolerability needed to be measured.
Research
Nitazoxanide for the treatment of infectious diarrhoea in the Northern Territory, Australia 2007-2012This paper examines the use of a new antibiotic to treat diarrhoea cause by Cryptosporidium infection in Australian Indigenous children.
Research
Th2-polarisation of cellular immune memory to neonatal pertussis vaccinationCurrent infant vaccination against pertussis in North America and Australia requires three doses of vaccines including diphtheria, tetanus and acellular...
Research assistant position in international project studying neutrophil and airway epithelial interactions in early cystic fibrosis lung disease.
News & Events
R U OK Day: Top tips for responding to someone who isn’t ‘OK’It’s important to ask, R U OK. If someone replies that they’re not, don’t panic – there are ways you can help.
News & Events
Meningococcal research paves way for vaccine useA series of The Kids Research Institute Australia studies looking at safety for Meningococcal ACWY vaccines in children has led the way for its use in Australia.