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ORIGINS has sub-projects exploring the link between a mother's diet during pregnancy and health outcomes of the child. Projects also explore nutrition and eating habits during the early years.
Determining the associations of sun exposure in early life on the development of non-communicable diseases.
The Antenatal Colostrum Expression (ACE) Study aims to determine whether hand expressing of colostrum in the last few weeks of pregnancy can help new mothers to breastfeed.
Helping families to unlock the mental and physical health benefits of connecting with nature and community through outdoor play - easily, and locally.
An experimental study linked to the Mums Minds Matter project, which aims to determine if pregnant women's willingness to engage in online wellbeing programs varies across types.
Auto-immune diseases such as diabetes, rheumatoid arthritis, muscular dystrophy and multiple sclerosis are associated with dysfunction in the microbiome. You need a balance of healthy bugs in your microbiome to keep it on track.
Research
Comparison of experiences in two birth cohorts comprising young families with children under four years during the initial Covid-19 lockdown in Australia and the UK: A qualitative studyThis study aims to understand the experience and impact of the initial COVID-19 lock-down in young families with children aged below 4 years. Free text questions were administered to participants in the ORIGINS (Australia) and Born in Bradford (UK) cohort studies to collect qualitative information on worries, concerns and enjoyable experiences during the pandemic.
Research
The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and DiseaseEarly onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORIGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections.
Research
The feasibility of a digital health approach to facilitate remote dental screening among preschool children during COVID-19 and social restrictionsTele-dentistry can be useful to facilitate screening of children, especially those living in rural and remote communities, and during the COVID-19 pandemic. This study evaluated the feasibility of tele-dental screening for the identification of early childhood caries (ECC) in preschoolers using an app operated by their parents with remote review by oral-health therapists.
Research
PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensityA significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.