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Research

Predicting respiratory hospital admissions in young people with cerebral palsy

Most risk factors for respiratory hospital admissions in young people with cerebral palsy are potentially modifiable

Research

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

The Human Phenotype Ontology is a standardized vocabulary of phenotypic abnormalities used by researchers, clinicians, informaticians and electronic health record systems

Research

Severity Assessment in CDKL5 Deficiency Disorder

A severity assessment was rapidly developed with input from multiple stakeholders. Refinement through ongoing validation is required for future clinical trials.

Research

Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII

Research

Temporal trends and socioeconomic differences in acute respiratory infection hospitalisations in children: an intercountry comparison of birth cohort studies

Admissions for ARI were higher in Western Australia and displayed greater socioeconomic disparities than England and Scotland, where ARI rates are increasing

Research

An urgent need for antimicrobial stewardship in Indigenous rural and remote primary health care

We write this perspective to raise awareness of antimicrobial resistance as an issue in Indigenous primary health care

Research

Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting

Occult maternal heart disease may be responsible for a substantial proportion of adverse pregnancy outcomes in low-resource settings

Research

Research Note: Adaptive trials

This Research Note has explored the strengths, risks and potential complexity of adaptive trials

Research

Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model

Here we investigate these features in an animal model related to autism spectrum disorder - the DVD-deficient rat

Research

Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy: A multi-country retrospective test negative design study, 2010–2016

Between 2010 and 2016, influenza vaccines offered moderate protection against laboratory-confirmed influenza-associated hospitalizations during pregnancy