The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout ce…
Platelets are anucleate blood cells that contain mitochondria and regulate blood clotting in response to injury. Mitochondria contain their own gene…
Eight The Kids Research Institute Australia-led projects will benefit from the latest round of WA Child Research Fund (WACRF) grants, announced this…
Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Pa…
Australian researchers have developed a new method to ‘wipe the memory’ of reprogrammed human cells to better mimic embryonic stem cells, in a discov…
The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial…
The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mito…
RNA-binding proteins and mitochondrial ribosomes have been found to be linchpins of mitochondrial gene expression in health and disease. The expandin…
Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with…
The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain…