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Frequency, Burden and Pathogens of Acute Respiratory Illness in Very Preterm Infants During Infancy

To describe the frequency, burden, and pathogen profile of acute respiratory illnesses in very preterm infants during the first year after neonatal i…

Adolescent health across Asia Pacific, 2000–23: a systematic analysis for the Global Burden of Disease Study 2023

The Asia Pacific region is home to more than half of the world's 1·93 billion adolescents (aged 10-24 years). Addressing adolescent health in this re…

Infection Triggered Encephalopathies in Australian Children: A National Multicentre Case Series 2013-2024

Infection Triggered Encephalopathy Syndrome (ITES) is a rare but potentially severe complication of infections in children. ITES is a syndrome of acu…

Lipid metabolism dysregulation in Parkinson's disease: A Mendelian randomization and transcriptomic analysis

Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which mechanisms linking metabolic dysregulation to neuronal vulnerability re…

Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials

Mucus plugs have been previously recognized as an important pathological feature in asthma and chronic obstructive pulmonary disease (COPD), but thei…

ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations

Cystic fibrosis (CF) is a genetic condition caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene. Recently licensed modulato…

Characteristics of uniphasic and biphasic anaphylaxis in infants and young toddlers: An analysis of clinical signs, predictors and management

Rates of anaphylaxis in early childhood are rising, yet there remains a paucity of data on age-specific presentations and outcomes. While prompt trea…

Multi-pathogen situational assessment and forecasting of respiratory disease in Aotearoa New Zealand

Real-time analysis of epidemic trends and forecasts can help support public health planning and the response to seasonal respiratory disease. Here, w…

Mucosal immune cell priming by intranasally delivered Haemophilus haemolyticus is associated with heterologous protection against influenza and nontypeable Haemophilus influenzae

Intranasal vaccines offer a needle-free strategy to enhance immunity to respiratory infections. We investigated the mechanism of action of a novel in…