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Whether airway mucosal acidification drives early progressive lung disease is controversial
The lung clearance index may be a useful surveillance tool for monitoring the presence and extent of lower airway inflammation and infection
This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and research
Research to further improve outcomes for people with CF is dependent upon well characterised, archived and accessible clinical specimens.
Join us for our Annual Community Lecture entitled "You Are What You Breathe" with Professor Stephen Holgate.
Dysregulated repair following epithelial injury is a key forerunner of disease in many organs, and the acquisition of a mesenchymal phenotype by the injured...
Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells.
The prevalence of LDCT-detected indeterminate lung nodules in 906 individuals with significant asbestos exposure was 8.5%, lower than many other CT studies
This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates
Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target