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Research
Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic LeukemiaInfants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL.
Research
Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic LeukemiaInfants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL.
Research
Effectiveness of trivalent flu vaccine in healthy young childrenThis paper reports some of the findings from the Western Australian Influenza Vaccine Effectiveness Study, commenced in 2008, to evaluate a program providing...
Research
Influenza vaccine effectiveness and uptake in children at risk of severe diseaseParticipation in the preschool influenza vaccination program remains low with parents unconvinced of the benefits and safety of influenza vaccine
Research
Adolescent dietary patterns are associated with lifestyle and family psychosocial factorsFew studies have examined the dietary patterns of adolescents and the social and environmental factors that may affect them during this life stage.
Research
The impact of influenza infection on young children, their family and the health care systemInfluenza infection in young children has a significant impact on medication use, absenteeism and the use of health care service
News & Events
Study to use eye masks and earplugs to teach preterm babies the rhythm of lifeResearchers will fit nearly 500 preterm babies with tiny eye masks and earplugs for the study.
News & Events
The Kids researchers finalists in Premier’s Science AwardsThe Kids Research Institute Australia has two researchers and an innovative science engagement initiative as finalists in the 2017 Premier’s Science Awards.
Research
From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progressGlioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients alike. Despite advancements in brain cancer research driven by a technological revolution, translating our understanding of glioblastoma pathogenesis into improved clinical outcomes remains a critical unmet need.
Research
Early morbidity and mortality following in utero exposure to selective serotonin reuptake inhibitorsThe early years of life have a profound effect on a child's developmental pathway.