Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy
Adaptive variants of P. aeruginosa that arise following long term bile exposure enables the emergence of ecologically competitive sub-populations
Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection
Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT
These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or struct…
Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients
Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage
This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates
A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF
Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target