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Vulnerable from the first breath - epithelial dysfunction and respiratory outcomes in children

We have been studying the importance of the epithelial cells lining the airways in the nose and lungs.

Epithelial Drivers of Neutrophil Plasticity in Early Cystic Fibrosis Lung Disease

Hallmarks of cystic fibrosis (CF) airway disease include bronchiectasis, airway inflammation by infiltrating polymorphonuclear neutrophils (PMNs) and…

Defective cell migration as a mechanism of dysregulated asthmatic airway repair

The findings from this study show that in children with asthma this protective barrier is different from children without asthma.

Children’s regenerative and genetic medicine program

The project aims to build capacity in regenerative medicine for children with respiratory diseases.

Improved diagnosis, treatment and prevention of recurrent tonsillitis

Strep A causes over 775 million infections each year world-wide, including over 615 million cases of tonsil infection (Strep throat).

BEAT-CF: Bayesian Evidence-Adaptive Tool to optimise management of Cystic Fibrosis

An innovative response-adaptive approach to driving improvements in health outcomes, applied to cystic fibrosis.

COPD-related modification to the airway epithelium permits intracellular residence of nontypeable haemophilus influenzae

Our findings indicate that COPD, cigarette smoke and macrolide antibiotics potentiate the susceptibility to persistent intracellular NTHi