Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting.
To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls.
Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease.
Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping"
The lung clearance index may be a useful surveillance tool for monitoring the presence and extent of lower airway inflammation and infection
Research to further improve outcomes for people with CF is dependent upon well characterised, archived and accessible clinical specimens.
This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for clinical practice and res…
CFTR-dependent imbalance of macrophage phenotypes and functions could contribute to the exaggerated inflammatory response seen in CF lung disease
The aim of this study is to characterize the role of currently available CT and MRI markers in clinical studies, and to discuss challenges with CF st…
In this review, we consider recent evidence regarding hypoxia and sterile inflammation in cystic fibrosis airways