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Research

Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage

Research

novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

This study thus identified a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability

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Mapping changes in housing in sub-Saharan Africa from 2000 to 2015

Our maps provide a baseline for measuring change and a mechanism to guide interventions during the era of the Sustainable Development Goals

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Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

These data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course

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Still keen and committed: piloting an instrument for identifying positive veteran teachers

Initial findings suggest the potential of the instrument in helping identifying positive veteran teachers within systems, as well as the voracity of the research approach

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Hospitalisations for maternal assault are associated with increased risk of child protection involvement

Child maltreatment allegation is common in children following a maternal hospitalisation for assault

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Soy Biodiesel Exhaust is More Toxic than Mineral Diesel Exhaust in Primary Human Airway Epithelial Cells

Exposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust

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Prednisolone Versus Dexamethasone for Croup: a Randomized Controlled Trial

The type of oral steroid seems to have no clinically significant impact on efficacy, both acutely and during the week after treatment

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The role and therapeutic implications of T cells in cancer of the lung

This review examines the role of T cells in lung cancer, discussing the direction and clinical significance of current and future immunotherapeutic strategies