Our findings define PTPN2 as a target for bolstering T-cell-mediated anti-tumour immunity and CAR T-cell therapy against solid tumours.
We established a pipeline to assess the effects of epigenetic modifiers on CD8+ T cell proliferation, differentiation, and efficacy in a preclinical…
Results support the emerging concept that CD103+ CD8+ tissue‐resident memory T cells are key mediators of cancer surveillance
Whole genome sequencing of poor and exceptional survivors identified a gain in Chromosome 19 that was exclusive to the exceptional survivors
These findings reveal a central role of the DG receptor, not only as a structural element, but also as a critical factor promoting mesenchymal-like G…
Our current Research Topic highlights the complexity of the relationship between the skin, immune system and skin cancer
The review will outline evidence of long-term health effects, possible mechanisms linking burn injury to long-term health and current research into b…
Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained
This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response
These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control