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Relationship between serum clozapine to N-desmethyclozapine ratio and cognitive performance among people with treatment-resistant schizophrenia

We evaluated the relationship of serum clozapine and N-desmethyl clozapine and their ratio and cognition among people with treatment-resistant schizophrenia, an area that has been sub-optimally researched. 

Citation:
Rai M, Wolde HF, John AP. Relationship between serum clozapine to N-desmethyclozapine ratio and cognitive performance among people with treatment-resistant schizophrenia. Australas Psychiatry. 2026.

Keywords:
Clozapine; cognition; serum levels: treatment-resistant schizophrenia

Abstract:
We evaluated the relationship of serum clozapine and N-desmethyl clozapine and their ratio and cognition among people with treatment-resistant schizophrenia, an area that has been sub-optimally researched.