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Proteomic Insights into Intrauterine Growth Restriction and Its Role in Asthma Pathogenesis

Intrauterine growth restriction (IUGR) increases risk of developing respiratory diseases such as asthma later in life. This study aims to characterize the effects of maternal hypoxia-induced IUGR on the lung proteome and identify key altered pathways relevant to asthma development in male and female adult offspring.

Citation:
Lv Y, Huang K, Thomas N, Li D, ……. Wang KCW, Schneider-Futschik EK. Proteomic Insights into Intrauterine Growth Restriction and Its Role in Asthma Pathogenesis. J Proteome Res. 2026;25(7):3572-85.

Keywords:
Airway remodeling; asthma; calcium signaling; inflammation; intrauterine growth restriction; lung development; maternal hypoxia; mitochondrial dysfunction; proteomics; ribosomal proteins

Abstract:
Intrauterine growth restriction (IUGR) increases risk of developing respiratory diseases such as asthma later in life. This study aims to characterize the effects of maternal hypoxia-induced IUGR on the lung proteome and identify key altered pathways relevant to asthma development in male and female adult offspring.