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Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models

Mesothelioma is a cancer derived from mesothelial cells, most commonly arising from the pleura or the peritoneum. Immune checkpoint therapy (ICT) has shown survival benefit for pleural mesothelioma, but little is known about the response in peritoneal mesothelioma. Most preclinical mesothelioma models involve subcutaneous cancer cell implantation, which lacks the relevant tumour microenvironment of peritoneal mesothelioma and does not resemble the clinical presentation.

Citation:
Orozco Morales ML, Lansley SM, Chin WL, Tilsed CM, …… Vitali BJ, Rwandamuriye FX, de Jong E, Kidman J, Zemek RM, Rinaldi CA, Lassmann T, Bosco A, ……. Lesterhuis WJ. Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models. Sci Rep. 2026;16(1).

Keywords:
Anatomical location; Immune checkpoint therapy; Mesothelioma; Tumour microenvironment

Abstract:
Mesothelioma is a cancer derived from mesothelial cells, most commonly arising from the pleura or the peritoneum. Immune checkpoint therapy (ICT) has shown survival benefit for pleural mesothelioma, but little is known about the response in peritoneal mesothelioma. Most preclinical mesothelioma models involve subcutaneous cancer cell implantation, which lacks the relevant tumour microenvironment of peritoneal mesothelioma and does not resemble the clinical presentation.