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Feasibility, Safety, and Impact of the Probiotics Lactiplantibacillus plantarum and Bifidobacterium longum subspecies infantis in Papua New Guinean Infants

Childhood mortality in low- or middle-income countries (LMICs) remains a major public health concern, with infections being a leading cause of infant death. Probiotics have shown promise in reducing infection-related morbidity and mortality in preterm infants, but their use in newborns born at or near term in LMICs requires further investigation.

Citation:
Ford RL, Greenhill AR, Sapura J, ……. Ong M, Kirarock W, ……. van den Biggelaar AHJ, Richmond PC. Feasibility, Safety, and Impact of the Probiotics Lactiplantibacillus plantarum and Bifidobacterium longum subspecies infantis in Papua New Guinean Infants: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2025;14:e73926.

Keywords:
Bifidobacterium longum subspecies infantis; Lactiplantibacillus plantarum; colonization; gut microbiota; infant health; neonatal infections; probiotics; synbiotics

Abstract:
Childhood mortality in low- or middle-income countries (LMICs) remains a major public health concern, with infections being a leading cause of infant death. Probiotics have shown promise in reducing infection-related morbidity and mortality in preterm infants, but their use in newborns born at or near term in LMICs requires further investigation.