NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts

Understanding the distribution and variation in NMR-based inflammatory markers is crucial to the evaluation of their clinical utility in disease prognosis and diagnosis. We applied high-resolution 1H NMR spectroscopy of blood plasma and serum to measure the acute phase reactive glycoprotein signals and the subregions of the lipoprotein-based Supramolecular Phospholipid Composite signals in a large multicohort population study.

Citation:
Lodge S, Masuda R, Nitschke P, ……. Currie A, Yeap BB, et al. NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts. Journal of Proteome Research. 2025;24(8):4191-201.

Keywords:
C-reactive protein; NMR spectroscopy; SARS-CoV-2; SPC; Supramolecular Phospholipid Composite signals; acute inflammation; blood plasma metabolic phenotyping; cardiovascular disease risk; chronic inflammation; diabetes; glycoproteins; inflammation.

Abstract:
Understanding the distribution and variation in NMR-based inflammatory markers is crucial to the evaluation of their clinical utility in disease prognosis and diagnosis. We applied high-resolution 1H NMR spectroscopy of blood plasma and serum to measure the acute phase reactive glycoprotein signals and the subregions of the lipoprotein-based Supramolecular Phospholipid Composite signals in a large multicohort population study.