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Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans

Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes.

Citation:
McGrath FM, Francis A, Fatovich DM, Macdonald SPJ et al. Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans. Clin Transl Immunology. 2022;11(12)

Keywords:
Allergy; anaphylaxis; microarray; platelet; sepsis; trauma

Abstract:
Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes.