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Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life

Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group.

Citation:
Read JF, Serralha M, Mok D, Holt B, Cruickshank M, Karpievitch YV, Broadhurst DI, Sly PD, Strickland DH, Reinke SN, Holt PG, Bosco A. Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life. Front Immunol. 2022;13

Keywords:
Innate immunity; interferon; lipopolysaccharide (LPS); multi-omics; pathogen recognition receptor (PRR); respiratory infection; systems biology

Abstract:
Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group.